Villarreal scored three late goals to advance to the Champions League quarter finals, while Juventus exited the competition for the third year in a row.Before substitute Gerard Moreno struck a 78th minute penalty after Daniele Rugani fouled Francis Coquelin, the Spanish team had not had a shot on target.
Pau Torres added a second with a six-yard finish after Juventus failed to deal with a corner.
After Matthijs De Ligt handled, Arnaud Danjuma made it 3-0 with another penalty.
“We had a gameplan and understood there would be difficult moments,” Villarreal manager Unai Emery remarked.
Villarreal will be in the last eight of the competition for the first time since 2008-09, and only the third time in club history, when the quarter final draw takes place on Friday at 11:00 GMT.
Juventus, the two time European champions, were overwhelming favorites to progress after a 1-1 draw in Spain last week, and they dominated the first half at the Allianz Stadium.
However, Dusan Vlahovic of Juventus, who scored in the first leg, struck the crossbar twice and was twice denied by Villarreal goalkeeper Gero Rulli, who also saved a shot from ex-Chelsea striker Alvaro Morata.
For the majority of the second half, Villarreal, led by former Arsenal manager Emery, had to defend deep and in numbers.
Rugani fouled substitute Coquelin in a rare attack, and referee Szymon Marciniak awarded the penalty after viewing it on a pitchside monitor.
Moreno, who had just been on the field for four minutes, kept his cool to put his team ahead as home goalkeeper Wojciech Szczesny tried but failed to stop the shot.
Juventus had been ousted in this stage of the competition the previous two years, losing to Lyon in 2020 and Porto in 2021, and had crumbled in the final 10 minutes of both games.
Torres doubled Villarreal’s lead after poor defense from a corner, before Danjuma, a former Bournemouth striker, converted another penalty kick in injury time.
“I think the team played well for nearly 75 minutes,” Juventus coach Massimiliano Allegri stated.
Villarreal elected to merely defend and block in the second half, although they did have one chance, which they took.
“It’s the same way with football: one game can alter everything.” ”
Villarreal defended with 11 men, ostensibly in an attempt to force extra time.
Then there was the goal, which altered everything.”
Villarreal, who are currently in seventh place in La Liga, qualified for the Champions League by winning the Europa League final last season, defeating Manchester United 11-10 in a spot shootout in which United goalkeeper David de Gea missed the deciding chance.